The distribution of heterophilic antigens and their relationship with autoimmune diseases.

ABSTRACT:

Introduction

Microbial infections are associated with the occurrence of autoimmune diseases, but the mechanisms of microbial infection inducing autoimmune diseases are not fully understood. The existence of heterophilic antigens between microorganisms and human tissues may explain part of the pathogenesis of autoimmune diseases. Here, we investigate the distribution of heterophilic antigens and its relationship with autoimmune diseases.

Methods

Monoclonal antibodies against a variety of microorganisms were prepared. The titer, subclass and reactivity of antibodies with microorganisms were identified, and heterophilic antibodies that cross-reacted with human tissues were screened by human tissue microarray. The reactivity of these heterophilic antibodies with different indivi

SUBMITTER: Sun L 

PROVIDER: S-EPMC10667719 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature