CGAS-STING Pathway Activation and Systemic Anti-Tumor Immunity Induction via Photodynamic Nanoparticles with Potent Toxic Platinum DNA Intercalator Against Uveal Melanoma.

ABSTRACT: The cGAS-STING pathway, as a vital innate immune signaling pathway, has attracted considerable attention in tumor immunotherapy research. However, STING agonists are generally incapable of targeting tumors, thus limiting their clinical applications. Here, a photodynamic polymer (P1) is designed to electrostatically couple with 56MESS-a cationic platinum (II) agent-to form NP^PDT -56MESS. The accumulation of NP^PDT -56MESS in the tumors increases the efficacy and decreases the systemic toxicity of the drugs. Moreover, NP^PDT -56MESS generates reactive oxygen species (ROS) under the excitation with an 808 nm laser, which then results in the disintegration of NP^PDT -56MESS. Indeed, the ROS and 56MESS act synergistically to damage DNA and mitochondria,

SUBMITTER: Tao H 

PROVIDER: S-EPMC10667795 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature