Mild-Photothermal Effect Induced High Efficiency Ferroptosis-Boosted-Cuproptosis Based on Cu₂ O@Mn₃ Cu₃ O₈ Nanozyme.

ABSTRACT: A core-shell-structured Cu₂ O@Mn₃ Cu₃ O₈ (CMCO) nanozyme is constructed to serve as a tumor microenvironment (TME)-activated copper ionophore to achieve safe and efficient cuproptosis. The Mn₃ Cu₃ O₈ shell not only prevents exposure of normal tissues to the Cu₂ O core to reduce systemic toxicity but also exhibits enhanced enzyme-mimicking activity owing to the better band continuity near the Fermi surface. The glutathione oxidase (GSHOx)-like activity of CMCO depletes glutathione (GSH), which diminishes the ability to chelate Cu ions, thereby exerting Cu toxicity and inducing cuproptosis in cancer cells. The catalase (CAT)-like activity catalyzes the overexpressed H₂ O₂ in the TME,

SUBMITTER: Chen W 

PROVIDER: S-EPMC10667815 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature