Metagenomic Insight into The Global Dissemination of The Antibiotic Resistome.

ABSTRACT: The global crisis in antimicrobial resistance continues to grow. Estimating the risks of antibiotic resistance transmission across habitats is hindered by the lack of data on mobility and habitat-specificity. Metagenomic samples of 6092 are analyzed to delineate the unique core resistomes from human feces and seven other habitats. This is found that most resistance genes (≈85%) are transmitted between external habitats and human feces. This suggests that human feces are broadly representative of the global resistome and are potentially a hub for accumulating and disseminating resistance genes. The analysis found that resistance genes with ancient horizontal gene transfer (HGT) events have a higher efficiency of transfer across habitats, suggesting that HGT may be the main driver for formin

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC10667823 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature