A Hyperflexible Electrode Array for Long-Term Recording and Decoding of Intraspinal Neuronal Activity.

ABSTRACT: Neural interfaces for stable access to the spinal cord (SC) electrical activity can benefit patients with motor dysfunctions. Invasive high-density electrodes can directly extract signals from SC neuronal populations that can be used for the facilitation, adjustment, and reconstruction of motor actions. However, developing neural interfaces that can achieve high channel counts and long-term intraspinal recording remains technically challenging. Here, a biocompatible SC hyperflexible electrode array (SHEA) with an ultrathin structure that minimizes mechanical mismatch between the interface and SC tissue and enables stable single-unit recording for more than 2 months in mice is demonstrated. These results show that SHEA maintains stable impedance, signal-to-noise ratio, single-unit yield, an

SUBMITTER: Fan J 

PROVIDER: S-EPMC10667843 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature