Footprint of pancreas infiltrating and circulating immune cells throughout type 1 diabetes development.

ABSTRACT:

Introduction

Type 1 diabetes (T1D) is defined by immune cell infiltration of the pancreas, in particular the islets of Langerhans, referred to as insulitis, which is especially prominent during the early disease stages in association with decreased beta cell mass. An in-depth understanding of the dynamics and phenotype of the immune cells infiltrating the pancreas and the accompanying changes in their profiles in peripheral blood during T1D development is critical to generate novel preventive and therapeutic approaches, as well as to find biomarkers for the disease process.

Methods

Using multi-parameter flow cytometry, we explored the dynamic changes of immune cells infiltrating the pancreas and the pancreatic draining lymph nodes (PLN), compared to those in peripheral blood

SUBMITTER: Bruggeman Y 

PROVIDER: S-EPMC10667927 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature