Occipital atrophy signature in prodromal Lewy bodies disease.

ABSTRACT:

Introduction

Dementia with Lewy bodies (DLB) is typically characterized by parietal, temporal, and occipital atrophy, but less is known about the newly defined prodromal phases. The objective of this study was to evaluate structural brain alterations in prodromal DLB (p-DLB) as compared to healthy controls (HC) and full-blown dementia (DLB-DEM).

Methods

The study included 42 DLB patients (n = 20 p-DLB; n = 22 DLB-DEM) and 27 HC with a standardized neurological assessment and 3-tesla magnetic resonance imaging. Voxel-wise analyses on gray-matter and cortical thickness were implemented to evaluate differences between p-DLB, DLB-DEM, and HC.

Results

p-DLB and DLB-DEM exhibited reduced occipital and posterior parieto-temporal volume and thickness, extending

SUBMITTER: Galli A 

PROVIDER: S-EPMC10668003 | biostudies-literature | 2023 Oct-Dec

REPOSITORIES: biostudies-literature