Body mass index, weight change in midlife, and dementia incidence: the Japan Public Health Center-based Prospective Study.

ABSTRACT:

Introduction

Insufficient evidence exists on the sex-specific associations of body mass index (BMI) and weight change through midlife with dementia incidence, especially in Asian populations.

Methods

For 37,414 Japanese residents aged 40 to 59 years, BMIs at baseline (year 1990 or 1993) and 10-year follow-ups were obtained. Weight changes between baseline and 10-year follow-ups were determined. Disabling dementia incidence from 2006 to 2016 was ascertained using long-term care insurance (LTCI) certifications. Hazard ratios (HRs) were computed.

Results

Increased dementia risk was observed with obesity at baseline and with underweight at 10-year follow-ups. Weight loss after baseline was at greater risk than weight gain. No sex difference was observed.

Discussion

SUBMITTER: Tashiro M 

PROVIDER: S-EPMC10668007 | biostudies-literature | 2023 Oct-Dec

REPOSITORIES: biostudies-literature