A novel nutraceutical formulation increases telomere length and activates telomerase activity in middle‑aged rats.

ABSTRACT: Telomeres are major contributors to cell fate and aging through their involvement in cell cycle arrest and senescence. The accelerated attrition of telomeres is associated with aging‑related diseases, and agents able to maintain telomere length (TL) through telomerase activation may serve as potential treatment strategies. The aim of the present study was to assess the potency of a novel telomerase activator on TL and telomerase activity in vivo. The administration of a nutraceutical formulation containing Centella asiatica extract, vitamin C, zinc and vitamin D3 in 18‑month‑old rats for a period of 3 months reduced the telomere shortening rate at the lower supplement dose and increased mean the TL at the higher dose, compared to pre‑treatment levels. TL was determined using

SUBMITTER: Tsatsakis A 

PROVIDER: S-EPMC10668076 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature