Genotype-guided new approach for dose optimisation of hydroxychloroquine administration in Chinese patients with SLE.

ABSTRACT:

Objectives

The study aims to investigate the impact of gene polymorphisms on blood hydroxychloroquine (HCQ) concentrations in patients with SLE and provide guidelines for individualised care.

Methods

489 Chinese patients with SLE taking HCQ for more than 3 months were collected in this study. The blood HCQ, desethylhydroxychloroquine (DHCQ) and desethylchloroquine concentrations were measured. The optimal blood concentration of HCQ was determined by receiver operating characteristic curve analysis. Single nucleotide polymorphisms of metabolic enzymes involved in HCQ metabolism were genotyped and the associations with treatment effects were investigated.

Results

The cut-off value of HCQ was 559.67 ng/mL, with sensitivity and specificity values of 0.51 and 0.89, respect

SUBMITTER: Xie H 

PROVIDER: S-EPMC10668244 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature