Association between fluid overload and mortality in children with sepsis: a systematic review and meta-analysis.

ABSTRACT:

Background

Sepsis is one of the main causes of morbidity and mortality worldwide. Fluid resuscitation is among the most common interventions and is associated with fluid overload (FO) in some patients. The objective of this systematic review and meta-analysis was to summarise the available evidence on the association between FO and morbimortality in children with sepsis.

Methods

A systematic search was carried out in PubMed/Medline, Embase, Cochrane and Google Scholar up to December 2022 (PROSPERO 408148), including studies in children with sepsis which reported more than 10% FO 24 hours after admission to intensive care. The risk of bias was assessed using the Newcastle-Ottawa scale. Heterogeneity was assessed using I², considering it absent if <25% and high if >

SUBMITTER: Fernandez-Sarmiento J 

PROVIDER: S-EPMC10668252 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature