Impact of SARS-CoV-2 infection on patients with systemic lupus erythematosus in England prior to vaccination: a retrospective observational cohort study.

ABSTRACT:

Objectives

Determine the prevaccination healthcare impact of COVID-19 in patients with systemic lupus erythematosus (SLE) in England.

Design

Retrospective cohort study of adult patients with SLE from 1 May to 31 October 2020.

Setting

Clinical Practice Research Datalink (CPRD) Aurum and Hospital Episode Statistics (HES) databases from general practitioners across England combining primary care and other health-related data.

Participants

Overall, 6145 adults with confirmed SLE diagnosis ≥1 year prior to 1 May 2020 were included. Most patients were women (91.0%), white (67.1%), and diagnosed with SLE at age <50 (70.8%). Patients were excluded if they had a COVID-19 diagnosis before 1 May 2020.

Primary and secondary outcome measures

Demographics and clinical

SUBMITTER: Rabe APJ 

PROVIDER: S-EPMC10668278 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature