Maresin1 ameliorates MSU crystal-induced inflammation by upregulating Prdx5 expression.

ABSTRACT:

Background

Maresin1 (MaR1) is a potent lipid mediator that exhibits significant anti-inflammatory activity in the context of several inflammatory diseases. A previous study reported that MaR1 could suppress MSU crystal-induced peritonitis in mice. To date, the molecular mechanism by which MaR1 inhibits MSU crystal-induced inflammation remains poorly understood.

Methods

Mousebone marrow-derived macrophages (BMDMs) were pretreated with MaR1 and then stimulated with FAs (palmitic, C16:0 and stearic, C18:0) plus MSU crystals (FAs + MSUc). In vivo, the effects of MaR1 treatment or Prdx5 deficiency on MSUc induced peritonitis and arthritis mouse models were evaluated.

Results

The current study indicated that MaR1 effectively suppressed MSUc induced inflammation in vitro and

SUBMITTER: Jiang H 

PROVIDER: S-EPMC10668345 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature