Discontinuation of antidepressant treatment: a retrospective cohort study on more than 20,000 participants.

ABSTRACT:

Background

Factors influencing antidepressant treatment discontinuation are poorly understood. In the present study, we aimed to estimate the prevalence of antidepressant treatment discontinuation and identify demographic characteristics, psychiatric comorbidities, and specific side effects associated with treatment discontinuation.

Methods

We leveraged data from the Australian Genetics of Depression Study (AGDS; N = 20,941) to perform a retrospective cohort study on antidepressant treatment discontinuation. Participants were eligible if they were over 18 years of age, had taken antidepressants in the past 4 years, and provided informed consent.

Results

Among the ten antidepressants studied, the highest discontinuation rates were observed for Mirtazapine (57.3%) and A

SUBMITTER: Garcia-Marin LM 

PROVIDER: S-EPMC10668351 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature