Phenome-wide association study on miRNA-related sequence variants: the UK Biobank.

ABSTRACT:

Background

Genetic variants in the coding region could directly affect the structure and expression levels of genes and proteins. However, the importance of variants in the non-coding region, such as microRNAs (miRNAs), remain to be elucidated. Genetic variants in miRNA-related sequences could affect their biogenesis or functionality and ultimately affect disease risk. Yet, their implications and pleiotropic effects on many clinical conditions remain unknown.

Methods

Here, we utilised genotyping and hospital records data in the UK Biobank (N = 423,419) to investigate associations between 346 genetic variants in miRNA-related sequences and a wide range of clinical diagnoses through phenome-wide association studies. Further, we tested whether changes in blood miRNA expression

SUBMITTER: Mustafa R 

PROVIDER: S-EPMC10668386 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature