Exploring the hypolipidemic effects of bergenin from Saxifraga melanocentra Franch: mechanistic insights and potential for hyperlipidemia treatment.

ABSTRACT:

Objective

The goal of this study was to explore the hypolipidemic effects of bergenin extracted from Saxifraga melanocentra Franch (S. melanocentra), which is a frequently utilized Tibetan medicinal plant known for its diverse bioactivities. Establishing a quality control system for black stem saxifrage is crucial to ensure the rational utilization of its medicinal resources.

Methods

A one-step polyamide medium-pressure liquid chromatography technique was applied to isolate and prepare bergenin from a methanol extract of S. melanocentra. A zebrafish model of hyperlipidemia was used to investigate the potential hypolipidemic effects of bergenin.

Results

The results revealed that bergenin exhibited substantial hypo efficacy in vivo. Specifically, bergenin significantly

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10668478 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature