Pathologically catalyzed physical coating restores the intestinal barrier for inflammatory bowel disease therapy.

ABSTRACT: Intestinal epithelia impairment of inflammatory bowel disease (IBD) leads to the leakage of bacteria and antigens and the consequent persistent immune imbalance. Restoring the epithelial barrier is a promising therapeutic target but lacks effective and safe clinical interventions. By identifying the catalase (CAT) presence in the IBD pathological environment, we herein develop a CAT-catalyzed pathologically coating on the damaged epithelial barrier to inhibit intestinal leakage for IBD therapy. With the codelivery of CaO₂ (a CAT substrate) and dopamine, the nanosystem can enable CAT-catalyzed oxygen (O₂) production and in-situ polymerization of dopamine and then yield a thin and integrative polydopamine (PDA) coating on the intestinal barrier due to the highly adhesiv

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC10668504 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature