Hypochloremia as a novel adverse prognostic factor in acute liver failure.

ABSTRACT:

Background and aims

Emerging evidence has identified hypochloremia as an independent predictor for mortality in multiple conditions including cirrhosis. Acute liver failure (ALF) is frequently complicated by electrolyte abnormalities. We investigated the prognostic value of hypochloremia in a large cohort of ALF patients from North America.

Methods

The Acute Liver Failure Study Group (ALFSG) registry is a longitudinal cohort study involving 2588 ALF patients enrolled prospectively from 32 North American academic centres. The primary outcome was a composite of 21-day all-cause mortality or requirement for liver transplantation (death/LT).

Results

Patients with hypochloremia (<98 mEq/L) had a significantly higher 21-day mortality rate (42.1%) compared with those with no

SUBMITTER: Wang J 

PROVIDER: S-EPMC10668517 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature