Admission Factor V Predicts Transplant-Free Survival in Acute Liver Failure.

ABSTRACT:

Background and aims

Traditional laboratory markers are insensitive in distinguishing between patients with acute liver failure (ALF) who will require urgent liver transplantation (LT) from those who will recover spontaneously, particularly within 24 h of presentation. Coagulation factor-V (FV) may improve the accuracy of outcome prediction in ALF due to its predominant synthesis in the liver and short half-life in plasma.

Methods

Patients enrolled in the ALF Study Group Registry from a single site had FV determined within 24 h of presentation (Derivation-Cohort). Area under the receiver operating characteristic curves (AUROC) dichotomized by ALF etiology [acetaminophen (APAP) or non-APAP] were constructed to evaluate the diagnostic performance of FV for transplant-free-survi

SUBMITTER: Patidar KR 

PROVIDER: S-EPMC10668526 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature