Association of APOE Haplotypes With Common Age-Related Ocular Diseases in 412,171 Individuals.

ABSTRACT:

Purpose

Apolipoprotein E4 (APOE4), a known risk factor for Alzheimer's disease, has controversially been associated with reduced risk of primary open-angle glaucoma (POAG) and age-related macular degeneration (AMD). Here, we sought to systematically quantify the associations of APOE haplotypes with age-related ocular diseases and to assess their scope and age-dependency.

Methods

We included genetic and registry data from 412,171 Finnish individuals in the FinnGen study. Disease endpoints were defined using nationwide registries. APOE genotypes were directly genotyped using Illumina and Affymetrix arrays or imputed using a custom Finnish reference panel. We evaluated the disease associations of APOE genotypes containing ε2 (without ε4) and ε4 (without ε2) compared with the ε3

SUBMITTER: Liuska PJ 

PROVIDER: S-EPMC10668614 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature