RNAseq Analysis of Livers from Pigs Treated with Testosterone and Nandrolone Esters: Selection and Field Validation of Transcriptional Biomarkers.

ABSTRACT: The use of anabolic-androgenic steroids (AASs) as growth promoters in farm animals is banned in the European Union, representing both an illicit practice and a risk for consumer health. However, these compounds are still illegally administered, often in the form of synthetic esters. This work aimed to characterize significant coding RNA perturbations related to the illicit administration of testosterone and nandrolone esters in fattening pigs. A total of 27 clinically healthy 90-day-old pigs were randomly assigned to test and control groups. Nine animals were treated with testosterone esters (Sustanon^®) and other nine with nandrolone esters (Myodine^®). At the end of the trial, liver samples were collected and analyzed using RNAseq, allowing the identification of 491 d

SUBMITTER: Benedetto A 

PROVIDER: S-EPMC10668810 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature