Structural and Functional Insights into the Stealth Protein CpsY of Mycobacterium tuberculosis.

ABSTRACT: Mycobacterium tuberculosis (Mtb) is an important and harmful intracellular pathogen that is responsible for the cause of tuberculosis (TB). Mtb capsular polysaccharides can misdirect the host's immune response pathways, resulting in additional challenges in TB treatment. These capsule polysaccharides are biosynthesized by stealth proteins, including CpsY. The structure and functional mechanism of Mtb CpsY are not completely delineated. Here, we reported the crystal structure of CpsY^201-520 at 1.64 Å. CpsY^201-520 comprises three β-sheets with five α-helices on one side and three on the other. Four conserved regions (CR1-CR4) are located near and at the base of its catalytic cavity, and three spacer segments (S1-S3) surround the catalytic cav

SUBMITTER: Liu D 

PROVIDER: S-EPMC10668966 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature