Prostaglandin E₂ Boosts the Hyaluronan-Mediated Increase in Inflammatory Response to Lipopolysaccharide by Enhancing Lyve1 Expression.

ABSTRACT: Macrophages are a highly versatile and heterogenic group of immune cells, known for their involvement in inflammatory reactions. However, our knowledge about distinct subpopulations of macrophages and their specific contribution to the resolution of inflammation remains incomplete. We have previously shown, in an in vivo peritonitis model, that inhibition of the synthesis of the pro-inflammatory lipid mediator prostaglandin E₂ (PGE₂) attenuates efficient resolution of inflammation. PGE₂ levels during later stages of the inflammatory process further correlate with expression of the hyaluronan (HA) receptor Lyve1 in peritoneal macrophages. In the present study, we therefore aimed to understand if PGE₂ might contribute to the regulation of Lyve1 and

SUBMITTER: Hog P 

PROVIDER: S-EPMC10669677 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature