Moving the Needle Forward in Genomically-Guided Precision Radiation Treatment.

ABSTRACT: Radiation treatment (RT) is a mainstay treatment for many types of cancer. Recommendations for RT and the radiation plan are individualized to each patient, taking into consideration the patient's tumor pathology, staging, anatomy, and other clinical characteristics. Information on germline mutations and somatic tumor mutations is at present rarely used to guide specific clinical decisions in RT. Many genes, such as ATM, and BRCA1/2, have been identified in the laboratory to confer radiation sensitivity. However, our understanding of the clinical significance of mutations in these genes remains limited and, as individual mutations in such genes can be rare, their impact on tumor response and toxicity remains unclear. Current guidelines, including those from the Nationa

SUBMITTER: Tam A 

PROVIDER: S-EPMC10669735 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature