Isoquercitrin from Apocynum venetum L. Exerts Antiaging Effects on Yeasts via Stress Resistance Improvement and Mitophagy Induction through the Sch9/Rim15/Msn Signaling Pathway.

ABSTRACT:

Background

With the development of an aging sociality, aging-related diseases, such as Alzheimer's disease, cardiovascular disease, and diabetes, are dramatically increasing. To find small molecules from natural products that can prevent the aging of human beings and the occurrence of these diseases, we used the lifespan assay of yeast as a bioassay system to screen an antiaging substance. Isoquercitrin (IQ), an antiaging substance, was isolated from Apocynum venetum L., an herbal tea commonly consumed in Xinjiang, China.

Aim of the study

In the present study, we utilized molecular-biology technology to clarify the mechanism of action of IQ.

Methods

The replicative lifespans of K6001 yeasts and the chronological lifespans of YOM36 yeasts were used to screen and

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10669743 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature