Exploring Circulating Long Non-Coding RNAs in Mild Cognitive Impairment Patients' Blood.

ABSTRACT: Mild cognitive impairment (MCI) is a transitional clinical stage prior to dementia. Patients with amnestic MCI have a high risk of progression toward Alzheimer's disease. Both amnestic mild cognitive impairment and sporadic Alzheimer's disease are multifactorial disorders consequential from a multifaceted cross-talk among molecular and biological processes. Non-coding RNAs play an important role in the regulation of gene expression, mainly long non-coding RNAs (lncRNAs), that regulate other RNA transcripts through binding microRNAs. Cross-talk between RNAs, including coding RNAs and non-coding RNAs, produces a significant regulatory network all through the transcriptome. The relationship of genes and non-coding RNAs could improve the knowledge of the genetic factors contributing to the pre

SUBMITTER: De Felice B 

PROVIDER: S-EPMC10669861 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature