Regulation of EZH2 Expression by INPP4B in Normal Prostate and Primary Prostate Cancer.

ABSTRACT: The phosphatases INPP4B and PTEN are tumor suppressors that are lost in nearly half of advanced metastatic cancers. The loss of PTEN in prostate epithelium initially leads to an upregulation of several tumor suppressors that slow the progression of prostate cancer in mouse models. We tested whether the loss of INPP4B elicits a similar compensatory response in prostate tissue and whether this response is distinct from the one caused by the loss of PTEN. Knockdown of INPP4B but not PTEN in human prostate cancer cell lines caused a decrease in EZH2 expression. In Inpp4b^-/- mouse prostate epithelium, EZH2 levels were decreased, as were methylation levels of histone H3. In contrast, Ezh2 levels were increased in the prostates of Pten^-/- male mice. Cont

SUBMITTER: Zhang M 

PROVIDER: S-EPMC10670027 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature