STAT2 Controls Colorectal Tumorigenesis and Resistance to Anti-Cancer Drugs.

ABSTRACT: Colorectal cancer (CRC) is a significant socioeconomic burden in modern society and is accountable for millions of premature deaths each year. The role of signal transducer and activator of transcription 2 (STAT2)-dependent signaling in this context is not yet fully understood, and no therapies targeting this pathway are currently being pursued. We investigated the role of STAT2 in CRC using experimental mouse models coupled with RNA-sequencing (RNA-Seq) data and functional assays with anti-cancer agents in three-dimensional tumoroids. Stat2^-/- mice showed greater resistance to the development of CRC in both inflammation-driven and inflammation-independent experimental CRC models. In ex vivo studies, tumoroids derived from Stat2^-/- mice with the multiple

SUBMITTER: Chiriac MT 

PROVIDER: S-EPMC10670206 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature