MicroRNA Profiling of Red Blood Cells for Lung Cancer Diagnosis.

ABSTRACT:

Background

Despite extensive endeavors to establish cell-free circulating biomarkers for lung cancer diagnosis, clinical adoption remains elusive. Noteworthy, emergent evidence suggests the pivotal roles of red blood cells (RBCs) and their derivatives in tumorigenesis, illuminating potential avenues for diagnostic advancements using blood cell-derived microRNAs (miRNAs).

Methods

We executed microarray analyses on three principal blood cell types-RBCs, peripheral blood mononuclear cells (PBMCs), and neutrophils-encompassing 26 lung cancer patients and 26 healthy controls. Validation was performed using droplet digital PCR within an additional cohort comprising 42 lung cancer and 39 control cases.

Results

Our investigation unearthed distinct miRNA profiles associated wi

SUBMITTER: Geng X 

PROVIDER: S-EPMC10670279 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature