Modelling 3D Tumour Microenvironment In Vivo: A Tool to Predict Cancer Fate.

ABSTRACT: Recently, many studies demonstrated the fundamental role of the tumour microenvironment (TME) in cancer progression. Here, we describe a method to visualize in 3D the behaviour of tumours in zebrafish embryos. We highlight two major actors of the TME, macrophages and vessels. This valuable tool is transposable to Patient-Derived Xenograft imaging in order to predict the fate of malignant tumours according to the dynamics of their TME.

SUBMITTER: Marines J 

PROVIDER: S-EPMC10670573 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature