Single-Cell Analysis Differentiates the Effects of p53 Mutation and p53 Loss on Cell Compositions of Oncogenic Kras-Driven Pancreatic Cancer.

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignant disease with a dismal prognosis. In the past decades, a plethora of genetically engineered mouse models (GEMMs) with autochthonous pancreatic tumor development have greatly facilitated studies of pancreatic cancer. Commonly used GEMMs of PDAC often harbor the oncogenic KRAS driver mutation (Kras^G12D), in combination with either p53 mutation by knock-in strategy (Trp53^R172H) or p53 loss by conditional knockout (Trp53^cKO) strategy, in pancreatic cell lineages. However, the systematic comparison of the tumor microenvironment between Kras^G12D; Trp53^R172H (KP^mut) mouse models and Kras^G12D; Trp53^cKO

SUBMITTER: Sun X 

PROVIDER: S-EPMC10670612 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature