The m⁷G Reader NCBP2 Promotes Pancreatic Cancer Progression by Upregulating MAPK/ERK Signaling.

ABSTRACT: PDAC is one of the most common malignant tumors worldwide. The difficulty of early diagnosis and lack of effective treatment are the main reasons for its poor prognosis. Therefore, it is urgent to identify novel diagnostic and therapeutic targets for PDAC patients. The m⁷G methylation is a common type of RNA modification that plays a pivotal role in regulating tumor development. However, the correlation between m⁷G regulatory genes and PDAC progression remains unclear. By integrating gene expression and related clinical information of PDAC patients from TCGA and GEO cohorts, m⁷G binding protein NCBP2 was found to be highly expressed in PDAC patients. More importantly, PDAC patients with high NCBP2 expression had a worse prognosis. Stable NCBP2-knockdown and

SUBMITTER: Xie J 

PROVIDER: S-EPMC10670634 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature