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Found in translation-Fibrosis in metabolic dysfunction-associated steatohepatitis (MASH).

ABSTRACT: Metabolic dysfunction-associated steatohepatitis (MASH) is a severe form of liver disease that poses a global health threat because of its potential to progress to advanced fibrosis, leading to cirrhosis and liver cancer. Recent advances in single-cell methodologies, refined disease models, and genetic and epigenetic insights have provided a nuanced understanding of MASH fibrogenesis, with substantial cellular heterogeneity in MASH livers providing potentially targetable cell-cell interactions and behavior. Unlike fibrogenesis, mechanisms underlying fibrosis regression in MASH are still inadequately understood, although antifibrotic targets have been recently identified. A refined antifibrotic treatment framework could lead to noninvasive assessment and targeted therapies that preserve hepatocellular function and restore the liver's architectural integrity.

SUBMITTER: Wang S

PROVIDER: S-EPMC10671253 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Found in translation-Fibrosis in metabolic dysfunction-associated steatohepatitis (MASH).

Wang Shuang S Friedman Scott L SL

Science translational medicine 20231004 716

Metabolic dysfunction-associated steatohepatitis (MASH) is a severe form of liver disease that poses a global health threat because of its potential to progress to advanced fibrosis, leading to cirrhosis and liver cancer. Recent advances in single-cell methodologies, refined disease models, and genetic and epigenetic insights have provided a nuanced understanding of MASH fibrogenesis, with substantial cellular heterogeneity in MASH livers providing potentially targetable cell-cell interactions a ...[more]

PMID: 37792957

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| S-EPMC11451593 | biostudies-literature

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| S-EPMC11470010 | biostudies-literature

Serum Protein Risk Stratification Score for Diagnostic Evaluation of Metabolic Dysfunction-Associated Steatohepatitis (MASH)

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2023-12-22 | GSE251855 | GEO

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DNA methylation analysis of liver samples from healthy individuals and patients with advanced metabolic dysfunction associated steatohepatitis (MASH)

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2024-03-01 | GSE241366 | GEO

A novel A2a adenosine receptor inhibitor effectively mitigates hepatic fibrosis in a metabolic dysfunction-associated steatohepatitis mouse model.

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| S-EPMC10929195 | biostudies-literature

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