PROTAC-Based Protein Degradation as a Promising Strategy for Targeted Therapy in Sarcomas.

ABSTRACT: Sarcomas are heterogeneous bone and soft tissue cancers representing the second most common tumor type in children and adolescents. Histology and genetic profiling discovered more than 100 subtypes, which are characterized by peculiar molecular vulnerabilities. However, limited therapeutic options exist beyond standard therapy and clinical benefits from targeted therapies were observed only in a minority of patients with sarcomas. The rarity of these tumors, paucity of actionable mutations, and limitations in the chemical composition of current targeted therapies hindered the use of these approaches in sarcomas. Targeted protein degradation (TPD) is an innovative pharmacological modality to directly alter protein abundance with promising clinical potential in cancer, even for undruggable p

SUBMITTER: Mancarella C 

PROVIDER: S-EPMC10671294 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature