Secretome as a Tool to Treat Neurological Conditions: Are We Ready?

ABSTRACT: Due to their characteristics, mesenchymal stem cells (MSCs) are considered a potential therapy for brain tissue injury or degeneration. Nevertheless, despite the promising results observed, there has been a growing interest in the use of cell-free therapies in regenerative medicine, such as the use of stem cell secretome. This review provides an in-depth compilation of data regarding the secretome composition, protocols used for its preparation, as well as existing information on the impact of secretome administration on various brain conditions, pointing out gaps and highlighting relevant findings. Moreover, due to the ability of MSCs to respond differently depending on their microenvironment, preconditioning of MSCs has been used to modulate their composition and, consequently, their the

SUBMITTER: da Silva AV 

PROVIDER: S-EPMC10671352 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature