New Derivatives of N-Hydroxybutanamide: Preparation, MMP Inhibition, Cytotoxicity, and Antitumor Activity.

ABSTRACT: Using a novel method of N-substituted succinimide ring opening, new N-hydroxybutanamide derivatives were synthesized. These compounds were evaluated for their ability to inhibit matrix metalloproteinases (MMPs) and their cytotoxicity. The iodoaniline derivative of N¹-hydroxy-N⁴-phenylbutanediamide showed the inhibition of MMP-2, MMP-9, and MMP-14 with an IC₅₀ of 1-1.5 μM. All the compounds exhibited low toxicity towards carcinoma cell lines HeLa and HepG2. The iodoaniline derivative was also slightly toxic to glioma cell lines A-172 and U-251 MG. Non-cancerous FetMSC and Vero cells were found to be the least sensitive to all the compounds. In vivo studies demonstrated that the iodoaniline derivative of N¹-hydrox

SUBMITTER: Balakina A 

PROVIDER: S-EPMC10671431 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature