Structural Insights into Protein-Aptamer Recognitions Emerged from Experimental and Computational Studies.

ABSTRACT: Aptamers are synthetic nucleic acids that are developed to target with high affinity and specificity chemical entities ranging from single ions to macromolecules and present a wide range of chemical and physical properties. Their ability to selectively bind proteins has made these compounds very attractive and versatile tools, in both basic and applied sciences, to such an extent that they are considered an appealing alternative to antibodies. Here, by exhaustively surveying the content of the Protein Data Bank (PDB), we review the structural aspects of the protein-aptamer recognition process. As a result of three decades of structural studies, we identified 144 PDB entries containing atomic-level information on protein-aptamer complexes. Interestingly, we found a remarkable increase in th

SUBMITTER: Troisi R 

PROVIDER: S-EPMC10671752 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature