Characterization of tissue and functional deficits in a clinically translational pig model of acute ischemic stroke.

ABSTRACT: The acute stroke phase is a critical time frame used to evaluate stroke severity, therapeutic options, and prognosis while also serving as a major tool for the development of diagnostics. To further understand stroke pathophysiology and to enhance the development of treatments, our group developed a translational pig ischemic stroke model. In this study, the evolution of acute ischemic tissue damage, immune responses, and functional deficits were further characterized. Stroke was induced by middle cerebral artery occlusion in Landrace pigs. At 24 h post-stroke, magnetic resonance imaging revealed a decrease in ipsilateral diffusivity, an increase in hemispheric swelling resulting in notable midline shift, and intracerebral hemorrhage. Stroke negatively impacted white matter integrity with

SUBMITTER: Kaiser EE 

PROVIDER: S-EPMC10671789 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature