Global Transcriptomic Changes Elicited by sodB Deletion and Menadione Exposure in Aspergillus nidulans.

ABSTRACT: Manganese superoxide dismutases (MnSODs) play a pivotal role in the preservation of mitochondrial integrity and function in fungi under various endogenous and exogenous stresses. Deletion of Aspergillus nidulans mnSOD/SodB increased oxidative stress sensitivity and apoptotic cell death rates as well as affected antioxidant enzyme and sterigmatocystin productions, respiration, conidiation and the stress tolerance of conidiospores. The physiological consequences of the lack of sodB were more pronounced during carbon starvation than in the presence of glucose. Lack of SodB also affected the changes in the transcriptome, recorded by high-throughput RNA sequencing, in menadione sodium bisulfite (MSB)-exposed, submerged cultures supplemented with glucose. Surprisingly, the differen

SUBMITTER: Pakozdi K 

PROVIDER: S-EPMC10671992 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature