Metabolomics Assessment of Volume Overload-Induced Heart Failure and Oxidative Stress in the Kidney.

ABSTRACT: The incidence of heart failure (HF) is increasing and is associated with a poor prognosis. Moreover, HF often coexists with renal dysfunction and is associated with a worsened outcome. In many experimental studies on cardiac dysfunction, the function of other organs was either not addressed or did not show any decline. Until now, the exact mechanisms for initiating and sustaining this interaction are still unknown. The objective of this study is to use volume overload to induce cardiac hypertrophy and HF in aortocaval fistula (ACF) rat models, and to elucidate how volume overload affects metabolic changes in the kidney, even with normal renal function, in HF. The results showed the metabolic changes between control and ACF rats, including taurine metabolism; purine metabolism; glycine, ser

SUBMITTER: Tang HY 

PROVIDER: S-EPMC10672757 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature