Metabolomic Profiling of Second-Trimester Amniotic Fluid for Predicting Preterm Delivery: Insights from NMR Analysis.

ABSTRACT: Preterm delivery (PTD) is a notable pregnancy complication, affecting one out of every ten births. This study set out to investigate whether analyzing the metabolic composition of amniotic fluid (AF) collected from pregnant women during the second trimester of pregnancy could offer valuable insights into prematurity. The research employed ¹H-NMR metabolomics to examine AF samples obtained from 17 women who gave birth prematurely (between 29⁺⁰ and 36⁺⁵ weeks of gestation) and 43 women who delivered at full term. The application of multivariate analysis revealed metabolites (dimethylglycine, glucose, myo-inositol, and succinate) that can serve as possible biomarkers for the prognosis and early diagnosis of preterm delivery. Additionally, pathway analysis unve

SUBMITTER: Kolvatzis C 

PROVIDER: S-EPMC10672859 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature