Effect of CM15 on Supported Lipid Bilayer Probed by Atomic Force Microscopy.

ABSTRACT: Antimicrobial peptides are key components of the immune system. These peptides affect the membrane in various ways; some form nano-sized pores, while others only produce minor defects. Since these peptides are increasingly important in developing antimicrobial drugs, understanding the mechanism of their interactions with lipid bilayers is critical. Here, using atomic force microscopy (AFM), we investigated the effect of a synthetic hybrid peptide, CM15, on the membrane surface comprising E. coli polar lipid extract. Direct imaging of supported lipid bilayers exposed to various concentrations of the peptide revealed significant membrane remodeling. We found that CM15 interacts with supported lipid bilayers and forms membrane-spanning defects very quickly. It is found that CM15 is cap

SUBMITTER: Walsh OD 

PROVIDER: S-EPMC10672887 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature