Differential Expression Analysis Utilizing Condition-Specific Metabolic Pathways.

ABSTRACT: Pathway analysis is ubiquitous in biological data analysis due to the ability to integrate small simultaneous changes in functionally related components. While pathways are often defined based on either manual curation or network topological properties, an attractive alternative is to generate pathways around specific functions, in which metabolism can be defined as the production and consumption of specific metabolites. In this work, we present an algorithm, termed MetPath, that calculates pathways for condition-specific production and consumption of specific metabolites. We demonstrate that these pathways have several useful properties. Pathways calculated in this manner (1) take into account the condition-specific metabolic role of a gene product, (2) are localized around defined metabo

SUBMITTER: Mattei G 

PROVIDER: S-EPMC10672963 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature