Study of the Anti-Inflammatory Mechanism of β-Carotene Based on Network Pharmacology.

ABSTRACT: β-carotene is known to have pharmacological effects such as anti-inflammatory, antioxidant, and anti-tumor properties. However, its main mechanism and related signaling pathways in the treatment of inflammation are still unclear. In this study, component target prediction was performed by using literature retrieval and the SwissTargetPrediction database. Disease targets were collected from various databases, including DisGeNET, OMIM, Drug Bank, and GeneCards. A protein-protein interaction (PPI) network was constructed, and enrichment analysis of gene ontology and biological pathways was carried out for important targets. The analysis showed that there were 191 unique targets of β-carotene after removing repeat sites. A total of 2067 targets from the three databases were integrated, 58 dupl

SUBMITTER: Wu S 

PROVIDER: S-EPMC10673508 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature