Tear and Saliva Metabolomics in Evaporative Dry Eye Disease in Females.

ABSTRACT: Accurate diagnosis of dry eye disease (DED) is challenging, and even today there is no gold standard biomarker of DED. Hypothesis-free global metabolomic studies of tears from DED patients have great potential to discover metabolites and pathways affected in the pathophysiology of DED, and to identify possible future biomarkers. These metabolites and biomarkers could be important for diagnosing and monitoring disease as well as for new therapeutic targets and strategies. As DED is associated with dry mouth, this study aimed to perform metabolomic analyses of tears and saliva from patients with decreased tear film break-up time but normal Schirmer test, and age-matched controls with both tear production and stability within physiological range. We applied strict inclusion criteria to reduce

SUBMITTER: Fineide FA 

PROVIDER: S-EPMC10673540 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature