Regulatory Functions of PurR in Yersinia pestis: Orchestrating Diverse Biological Activities.

ABSTRACT: The bacterium Yersinia pestis has developed various strategies to sense and respond to the complex stresses encountered during its transmission and pathogenic processes. PurR is a common transcriptional regulator of purine biosynthesis among microorganisms, and it modulates the transcription level of the pur operon to suppress the production of hypoxanthine nucleotide (IMP). This study aims to understand the functions and regulatory mechanisms of purR in Y. pestis. Firstly, we constructed a purR knockout mutant of Y. pestis strain 201 and compared certain phenotypes of the null mutant (201-ΔpurR) and the wild-type strain (201-WT). The results show that deleting purR has no significant impact on the biofilm formation, growth rate, or v

SUBMITTER: Xiao L 

PROVIDER: S-EPMC10673613 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature