Runx factors launch T cell and innate lymphoid programs via direct and gene network-based mechanisms.

ABSTRACT: Runx factors are essential for lineage specification of various hematopoietic cells, including T lymphocytes. However, they regulate context-specific genes and occupy distinct genomic regions in different cell types. Here, we show that dynamic Runx binding shifts in mouse early T cell development are mostly not restricted by local chromatin state but regulated by Runx dosage and functional partners. Runx cofactors compete to recruit a limited pool of Runx factors in early T progenitor cells, and a modest increase in Runx protein availability at pre-commitment stages causes premature Runx occupancy at post-commitment binding sites. This increased Runx factor availability results in striking T cell lineage developmental acceleration by selectively activating T cell-identity and innate lympho

SUBMITTER: Shin B 

PROVIDER: S-EPMC10673614 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature