Quercetin-1,2,3-Triazole Hybrids as Multifunctional Anti-Alzheimer's Agents.

ABSTRACT: The number of patients with Alzheimer's disease (AD) continues to rise and, despite the efforts of researchers, there are still no effective treatments for this multifaceted disease. The main objective of this work was the search for multifunctional and more effective anti-Alzheimer agents. Herein, we report the evaluation of a library of quercetin-1,2,3-triazole hybrids (I-IV) in antioxidant, hydrogen peroxide-induced oxidative stress protection, and cholinesterases (AChE and BuChE) inhibitory activities. Hybrids IIf and IVa-d showed potent in vitro inhibitory activity on eqBuChE (IC₅₀ values between 11.2 and 65.7 μM). Hybrid IIf, the best inhibitor, was stronger than galantamine, displaying an IC₅₀ value of 11.2 μM for eqBuC

SUBMITTER: Carreiro EP 

PROVIDER: S-EPMC10673615 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature