Neuromodulation for Gastroesophageal Reflux Disease: A Systematic Review.

ABSTRACT:

Background and objectives

In this systematic review, we evaluated the efficacy, mechanisms and safety of three neuromodulation therapies in patients with gastroesophageal reflux disease (GERD), including the effect of neuromodulation therapies on symptoms and key GERD pathophysiologies, lower esophageal sphincter (LES) pressure, esophageal motility, gastric motility, and parasympathetic activity. The first therapy is LES electrical stimulation using an implantable electrical stimulator, the second is transcutaneous electrical acustimulation, and the third is manual acupuncture.

Methods

A systematic review of literature according to the PRISMA guidelines was performed. Online databases searched include Medline (Ovid), Embase, and PubMed. Studies were assessed for inclusion an

SUBMITTER: Woo JY 

PROVIDER: S-EPMC10673618 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature