Quantitative Synthesis of Personalized Trials Studies: Meta-Analysis of Aggregated Data Versus Individual Patient Data.

ABSTRACT: We have entered an era in which scientific knowledge and evidence increasingly inform research practice and policy. As there is an exponential increase in the use of personalized trials, there is a remarkable growing interest in the quantitative synthesis of personalized trials. One technique that is developed and can be applied for this purpose is meta-analysis. Meta-analysis involves the quantitative integration of effect sizes from several personalized trials. In this study, aggregated data (AD) and individual patient data (IPD) methods for meta-analysis of personalized trials are discussed, together with an empirical demonstration using a subset of a real meta-analytic data set. For the empirical demonstration, 26 personalized trials received usual care and yoga intervention in a rando

SUBMITTER: Moeyaert M 

PROVIDER: S-EPMC10673630 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature